(a) Nanotweezers to regulate enzyme activity [49]; (b) Tubular nanoreactor with switchable lid to control the flowthrough of the reaction compounds [53]; (c) DNA origami nanoactuator that can be driven by, e.g., single-stranded DNA (ssDNA) strands or restriction enzymes [54]; (d) Aptamer-based logical molecular circuit to control thrombin activity [55]. (a) is reproduced with permission from [49] Copyright Nature Publishing Group, 2013. (b) is reproduced with permission from [53]. Copyright The Royal Society of Chemistry, 2016. (c) is reproduced with permission from [54]. Published by Nature Publishing Group, 2016. (d) is reproduced with permission from [55]. Copyright American Chemical Society, 2012.