Fig. 3. SAMNet identifies integrated network for ALL progression. The purple/green edges represent interactions from the in vivo/in vitro screens. RNAi hits are represented by a shaded square; the shading refers to the extent of depletion in the original screen. A diamond is a transcription factor selected by SAMNet; those that are shaded are also hits from the shRNA screen. All white-face nodes are hidden targets selected by the algorithm. Node border color represents fractional representation in a family of 100 random networks. Those without pink/orange border coloring are non-specific. The thickness of the interaction line represents the amount of flow captured by that interaction; qualitatively this reflects an edge with higher interaction confidence in the underlying interactome. Downstream mRNA pictured in Fig. 4. Red arrows indicate where Wwp1, Hgs, Lmo2, and Pogz exist within the network. A high-resolution image is available: ; http://fraenkel-nsf.csbi.mit.edu/psiquic/.