Fig. 4. SAMNet selects transcription factors that explain genes with greatest differential expression. The transcription factors and differentially expressed genes are represented as triangles and octagons respectively. Grey shading on the transcription factors represents the extent of depletion in the original screen. Shading on the differentially expressed genes reflects either down-regulation (green) or up-regulation (purple) in the in vivo screen relative to the in vitro screen. The thickness of the interaction line represents the amount of flow captured by that interaction; qualitatively this reflects an edge with higher interaction confidence in the underlying interactome. Node border color represents fractional representation in a family of 100 random networks. Those without pink/orange border coloring are non-specific. A high-resolution image is available: ; http://fraenkel-nsf.csbi.mit.edu/psiquic/.
