Table 2. Evaluated dose regimens for piperaquine simulations.

Dose Regimen	Body Weight (kg)	Number of Tablets/Day	PQP/Day (mg/kg)	Total Dosage (mg/kg) by Body Weight Group
				All		5–15 kg		>15 kg
				Minimum	Maximum	Minimum	Maximum	Minimum	Maximum
Sigma-Tau				38.4	80.1	39.9	73.8	38.4	80.1
	5–6	0.25	13.3–16.0
	7–12	0.5	13.3–22.9
	13–23	1	13.9–24.6
	24–35	2	18.3–26.7
	36–74	3	13.0–26.7
	75–100	4	12.8–17.1
Beijing Holley-Cotec				28.8	96	39.9	68.7	28.8	96
	5–6	0.25	13.3–16.0
	7–9	0.5	17.8–22.9
	10–14	0.5*	15.2–21.3
	15–19	1	16.8–21.3
	20–39	2	16.4–32.0
	40–100	3	9.60–24.6
Optimised				48	96	64	96	48	84.7
	5–7	0.5	22.9–32.0
	8–10	0.75	24.0–30.0
	11–16	1	20.0–29.1
	17–24	1.5	20.0–28.2
	25–35	2	18.3–25.6
	36–59	3	16.3–26.7
	60–79	4	16.2–21.3
	80–100	5	16.0–20.0

PQP/day is the total daily dosage of piperaquine phosphate (mg/kg). Minimum total dosage is the minimum total piperaquine dosage an individual receives with each dose regimen. Maximum total dosage is the maximum total piperaquine dosage an individual receives with each dose regimen.

*One tablet given on the first day and half a tablet on the second and third day.