Table 3.

The ICET-A guidelines for the monitoring of HRT in female TM patients with hypogonadism.

	Start of treatment (baseline)	Each visit	3–6 Months	Yearly	1–2 years
Physical examination and compliance	✓	✓
Blood pressure and Tanner’s stage assessment	✓		✓
Pelvic exam in sexually active patients	✓			✓
Assessment of iron overload (*)	✓		✓
Basal FSH, LH and 17β estradiol levels and thyroid status	✓			✓
Pelvic and abdominal US
Renal and liver function	✓			✓
Fasting lipids	✓			✓
Family and personal history of VTE and Thrombophilia screening	✓			✓
Basal glucose and insulin glucose and HOMA-IR assessment	✓		✓
Oral glucose tolerance test (OGTT)	In selected cases			✓
BMD of lumbar spine/femoral neck	✓				✓

Abbreviations. HOMA-IR Homeostatic Model Assessment of Insulin Resistance; BMD- bone mineral density; US-ultrasound;

^*Serum ferritin levels every three months, Magnetic Resonance Imaging (Liver iron concentration -LIC) at baseline and in one year if LIC >7mg/ and in two years if LIC < 7mg).