Table 2.
Risk of MS: Logistic regression results modeling the odds of MS (cases) compared to Non‐MS (controls). Pre and Postpubertala boys and girls modeled separately. Odds‐ratios with 95% confidence intervals (CI) are shown
| Model | Characteristic | Unadjusted Odds‐Ratio (95% CI) | P‐value | Adjustedc Odds‐Ratio (95% CI) | P‐value |
|---|---|---|---|---|---|
| Postmenarcheal Girls: (N = 181, 83 cases) | BMI‐for‐age z‐score | 1.68 (1.21, 2.34) | 0.002 | 1.60 (1.12, 2.27) | 0.009 |
| Menarcheal Age | 0.83 (0.65, 1.05) | 0.116 | 0.97 (0.75, 1.26) | 0.841 | |
| Premenarcheal Girls (N = 57, 19 cases) | BMI‐for‐age z‐score | 1.48 (0.88, 2.51) | 0.143 | 1.12 (0.61, 2.08) | 0.711 |
|
All Boys (N = 207, 59 cases) |
BMI‐for‐age z‐score | 1.42 (1.09, 1.86) | 0.009 | 1.43 (1.08, 1.88) | 0.011 |
| Advanced Maturityb | 1.09 (0.47, 2.54) | 0.844 | 0.99 (0.41, 2.38) | 0.975 |
BMI, body mass index
a
Postpubertal defined as postmenarche (females) or Tanner II ≥ 2 (males).
b
A boy has advanced maturity if his age is more than 1 standard deviation below the average age of controls with the same Tanner stage (pubic hair). Boys in stage I are not advanced. Tanner stage must be measured within 1 year of first symptoms for cases.
c
Adjusted for factors shown and race/ethnicity.
Bolded are statistically significant. p<0.05