Table 3.
Linear regression analysis results for age at symptom onset. Pre and postpubertala boys and girls modeled separately. Regression coefficients with 95% confidence intervals (CI) are shown
| Model | Characteristic | Univariable Linear Regression Coefficient (95% CI) | P‐valuec | Multivariable Linear Regression Coefficient (95% CI) | P‐valuec |
|---|---|---|---|---|---|
| Postmenarcheal onset Girls: (N = 83) | Interceptd | 13.0 (8.9, 17.0) | <0.001 | ||
| BMI‐for‐age z‐score | −0.5 (−0.9, −0.0) | 0.031 | −0.4 (−0.8, 0.0) | 0.072 | |
| Menarcheal Age | 0.3 (−0.0, 0.6) | 0.059 | 0.3 (−0.1, 0.6) | 0.096 | |
| Black NH | −0.4 (−1.4, 0.7) | 0.181 | −0.2 (−1.3, 0.8) | 0.090 | |
| Other NH | −1.3 (−2.6, −0.0) | −1.6 (−2.9, −0.4) | |||
| Hispanic‐Latino | −0.7 (−1.6, 0.2) | −0.5 (−1.3, 0.4) | |||
| White NH | Reference | Reference | |||
| Premenarcheal onset Girls (N = 19) | Interceptd | 12.0 (9.6, 14.4) | <0.001 | ||
| BMI‐for‐age z‐score | −1.3 (−3.4, 0.8) | 0.221 | −0.0 (−2.0, 2.0) | 0.993 | |
| Black NH | −3.4 (−7.6, 0.8) | 0.012 | −3.4 (−7.8, 1.0) | 0.031 | |
| Other NH | −4.8 (−8.6, −1.1) | −4.8 (−8.8, −0.9) | |||
| Hispanic‐Latino | −6.1 (−9.6, −2.5) | −6.1 (−10.3, −1.9) | |||
| White NH | Reference | Reference | |||
| Pubertal/Postpubertal Boys (N = 50) | Interceptd | 15.4 (14.7, 16.2) | <0.001 | ||
| BMI‐for‐age z‐score | −0.1 (−0.6, 0.4) | 0.610 | 0.2 (−0.2, 0.7) | 0.329 | |
| Advanced Sexual Maturityb | −2.8 (−4.2, −1.4) | <0.001 | −3.6 (−5.2, −1.9) | <0.001 | |
| Black NH | 0.0 (−3.2, 3.2) | 0.689 | −0.4 (−3.2, 2.4) | 0.374 | |
| Other NH | −0.6 (−3.8, 2.6) | 2.4 (−0.8, 5.5) | |||
| Hispanic‐Latino | −0.8 (−2.1, 0.5) | −0.3 (−1.5, 1.0) | |||
| White NH | Reference | Reference | |||
| Prepubertal Boys (N = 9) | Interceptd | 9.5 (4.0, 15.1) | 0.009 | ||
| BMI‐for‐age z‐score | −1.5 (−3.1, 0.0) | 0.055 | −1.6 (−3.9, 0.6) | 0.117 | |
| Black NH | −1.6 (−9.6, 6.4) | 0.758 | −0.0 (−7.2, 7.2) | 0.674 | |
| Other NH | −2.3 (−12.4, 7.9) | −3.1 (−11.9, 5.6) | |||
| Hispanic‐Latino | 1.2 (−6.0, 8.3) | 0.9 (−5.2, 7.0) | |||
| White NH | Reference | Reference |
BMI, body mass index.
a
Postpubertal defined as postmenarche (females) or Tanner stage (pubic hair) ≥ 2 (males).
b
A boy has advanced maturity if his age is more than 1 standard deviation below the average age of controls with the same Tanner stage (pubic hair). Boys in stage I are not advanced. Tanner stage must be measured within 1 year of first symptoms for cases.
c
P‐values from Type III tests.
d
Univariable regression coefficients are from separate models, each with their own intercept term.
Bolded are statistically significant, p<0.05