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. 2016 Oct 18;3(12):908–923. doi: 10.1002/acn3.364

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© 2016 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Celecoxib effects in vivo. (A) Raw electroencephalogram (EEG) recording of a seizure (top). First derivative of EEG recording (bottom); spikes marked automatically by dClamp illustrated with red dots. (B) Raster plot of seizure activity in rats (n = 8). Celecoxib treatment illustrated in pink; placebo treatment illustrated in yellow; rats removed from experiment illustrated with dashed line. (C) Average number of seizures per rat per day decreases following celecoxib treatment and increases following placebo treatment; data expressed as mean ± SEM (paired samples t‐test, *P = 0.0116). (D) Ratio of average number of seizures per rat per day showing effect of celecoxib treatment compared to placebo treatment. (E) Randomization of the order of interseizure intervals for each rat over total time course of experiment demonstrated two cases of false significance (P ≤ 0.0116, marked in red) for 1000 iterations.