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The scheme shows that activation of EGFR triggers PI3K/AKT/mTOR pathways cascade, which increases the translation of hypoxia‐inducible factors. Moreover, hypoxia can stabilize NICD by interaction with HIF‐1α. TKISs, tyrosine kinase inhibitors; EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; PI3K/AKT, phosphatidylinositide 3‐kinases; mTOR, mechanistic target of rapamycin; NICD, intracellular domain of Notch; HIF‐1α, hypoxia‐inducible factors.
