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. 2016 Oct 28;5(12):3512–3519. doi: 10.1002/cam4.900

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© 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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miR‐146a silencing counteracted the effects of PVT1 knockdown on prostate cancer cells. (A–C) miR‐146a silencing counteracted the effect of PVT1 knockdown on cell viability of prostate cancer cells. LNCaP, PC‐3, and DU145 cells were infected with LNA‐Ctrl or LNA‐anti‐miR‐146a for 24 h and then infected with si‐PVT1. Relative cell numbers were evaluated using MTT analysis at the indicated time points. **P < 0.01 indicates si‐Ctrl+LNA‐Ctrl versus si‐PVT1 + LNA‐Ctrl, ^# P < 0.05, ^## P < 0.01 indicates si‐Ctrl+LNA‐Ctrl versus si‐Ctrl+ LNA‐anti‐miR‐146a. (D–F) miR‐146a silencing counteracted the effect of PVT1 knockdown on the apoptosis of prostate cancer cells. The percentage of apoptotic cells were analyzed with FACS. FACS, fluorescence‐activated cell sorter.