Table 1.
Formulation | Particle size (nm) |
PDI | Zeta potential (mV) |
DL% | EE% | CE% | SD |
---|---|---|---|---|---|---|---|
SP141NP | 79.9±1.0 | 0.280±0.012 | −7.2±0.2 | 16.5±1.4% | 98.9±1.3% | N/A | N/A |
SP141FcNP | 85.5±2.8 | 0.291±0.013 | −7.0±0.3 | 16.4±1.2% | 98.6±1.1% | 57.9%±1.8% | 52±2 |
Abbreviations: SP141NP, SP141-loaded PEG-PCL nanoparticles; SP141FcNP, SP141-loaded Fc-conjugated PEG-PCL nanoparticles; PDI, Polydispersity; DL%, Drug Loading (%); EE%, Encapsulation Efficiency (% W/W); CE%, Fc Conjugation Efficiency (%); SD, Fc Surface Density