Table 1.
NKx2.2Δendo and Nkx2.2KO E15.5 RNA-Seq - Gene expression changes in select transcription factors and pancreatic hormones.
|
Nkx2.2△endo fold change |
Adjusted p-value |
Nkx2.2KO fold change |
Adjusted p-value |
|
|---|---|---|---|---|
|
Transcription factors |
||||
Arx |
2.16 |
3.26E-09 |
1.57 |
0.0031 |
MafA |
0.11 |
3.39E-06 |
0.13 |
0.0040 |
MafB |
0.43 |
1.31E-10 |
0.22 |
3.92E-38 |
NeuroD1 |
0.89 |
1 |
0.32 |
3.01E-23 |
Neurog3 |
1.11 |
1 |
0.59 |
0.0198 |
Nkx6.1 |
0.77 |
1 |
0.82 |
0.9684 |
Pax4 |
1.02 |
1 |
0.73 |
0.4762 |
Pax6 |
0.36 |
1.07E-06 |
0.21 |
2.84E-30 |
Pdx1 |
0.88 |
1 |
1.25 |
0.7916 |
Rfx6 |
1.00 |
1 |
0.63 |
0.0013 |
Sox9 |
0.94 |
1 |
1.08 |
1 |
|
Pancreatic hormones |
||||
Gast |
0.19 |
2.16E-07 |
0.09 |
2.63E-09 |
Gcg |
0.16 |
2.23E-12 |
0.01 |
4.64E-16 |
Ghrl |
8.27 |
1.94E-31 |
6.43 |
6.72E-16 |
Ins1 |
0.03 |
4.84E-24 |
0.00 |
4.32E-11 |
Ins2 |
0.01 |
2.99E-55 |
0.00 |
1.48E-11 |
Ppy |
10.08 |
4.99E-42 |
2.17 |
7.15E-05 |
Sst |
1.14 |
1 |
0.45 |
0.5130 |