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. Author manuscript; available in PMC: 2018 Jan 15.
Published in final edited form as: J Immunol. 2016 Dec 5;198(2):741–748. doi: 10.4049/jimmunol.1601651

Figure 2. Dissemination of Mtb to extrapulmonary sites is influenced by TLR2 on non-hematopoietic cells.

Figure 2

Bacterial burden in the spleen, liver, and mediastinal lymph nodes (MLN) was evaluated in bone marrow chimeric Mtb-infected mice at weeks 8 and 14. Time points were performed after separate aerosol infections with 4–5 mice used per group. The number of viable bacteria was determined by plating serial dilutions of homogenates onto 7H11 agar plates. Colonies were counted 21 days after incubation at 37°C to determine CFU. Data are presented as mean CFU counts ± SEM. Significance was determined by Bonferroni Multiple Comparisons test of One-Way ANOVA. *p<.05; **p<.01. *Denotes significance as compared to NH-TLR2KO. Data are representative of two independent experiments with similar results.