Fig 3. Rescue of Clk^AR ARLI phenotype by Clk expression in the PDF-expressing pacemaker neurons.

(A) Reintroducing Clk expression in the PDF neurons of Clk^AR flies (pdf>Clk;Clk^AR) significantly rescued the premature locomotor decline of the Clk^AR mutation. (B) Clk overexpression in PDF neurons had no effect on SING decline in a wild-type background. Graphs display the means ± SEM from 2 independent experiments.