Table 1. In vitro characterization of lovastatin-encapsulating PLGA nanoparticles.

Empty- or lovastatin-encapsulating PLGA nanoparticles (NP) were prepared by oil-in-water emulsion. NP size was measured with dynamic light scattering and percent drug loading (DL) was quantified by HPLC. EE, percent encapsulation efficiency of drug loading. Data shown are the means ± SEM, n=3–4 sample preparations.

PLGA ratio:	85:15	85:15	85:15	50:50
NP size (nm)	252.9 ± 33.8	230.8 ± 5.9	299.6 ± 5.3	256.8 ± 9.8
DL (Theoretical)	6.25	25.0	0	6.25
DL (Actual)	6.5 ± 0.3	27.3± 4.2	0	5.5 ± 0.3
EE	104.3 ± 4.1	109.2 ± 4.2	N/A	87.4 ± 4.4