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. Author manuscript; available in PMC: 2018 Jan 9.
Published in final edited form as: Cancer Cell. 2016 Dec 15;31(1):21–34. doi: 10.1016/j.ccell.2016.11.005

Figure 1. ChAT+ tuft cells and nerves expand during carcinogenesis.

Figure 1

(A) Dclk1 staining (red) in Chat-GFP (green) mice antrum. Blue arrow indicates tuft cells, and yellow arrow indicates nerves. (B) (Left) Peripherin staining (red) in Chat-GFP mice antrum. Arrows indicate GFP+ nerves. (Right) Dclk1 staining (red) in Lgr5-GFP mice antrum. (C) Chat-GFP expression with or without MNU treatment (3 months and 9 months after the beginning of MNU). (D) The number of ChAT+ epithelial cells per gland in MNU-treated or untreated stomachs. Total 100 glands per group are analyzed. (E) Cell position of ChAT+ stromal cells in MNU-treated or untreated stomachs. Total 50 glands per group are analyzed. Means ± SEM. *p < 0.05 (ANOVA). DAPI = blue. Bars = 20 m. See also Figure S1.