Figure 2. Changes in health benefits and resources use for the baseline and influential parameters assumptions.

The figure displays the tradeoffs in reductions in lifetime cervical cancer risk, monetary costs, number of cytology exams, colposcopy referral rates, and precancer treatments for 5-yearly self-sampling (under Scenarios A and B) or 10-yearly self-sampling strategies compared with the current 2-reminder letter policy. Scenario A assumed that respondents to self-sampling had moderate under-screening histories (i.e., screened every 8-, or 10-years in the absence of self-sampling), while Scenario B assumed that respondents to self-sampling included women with moderate and severe under-screening histories (i.e., screen every 8-, 10-, 20-years or never-screened). For this scenario, we assumed there was a gradient of response related to screening history, i.e., women with more severe screening histories were less likely to respond compared with women with moderate screening histories.