Fig. 5.

Dosage of Tm differentially influences the Erk1/2 and p38 signaling pathways. a, b BHK21 cells were exposed to varied doses of Tm for a period of 8 h and then assessed for activation of the Erk1/2 (p42/p44) and p38 signaling pathways. Relative intensity of activation was determined by normalizing bands to the vehicle-treated control. Erk1/2 show elevated phosphorylation (activation) over moderate doses of Tm, and activation of the p38 stress-activated protein kinase increased with Tm dose. c Anti-apoptotic regulatory proteins survivin and cIAP1 decrease in BHK21 cells with increasing loss associated with higher doses of Tm. All blots shown are representative of at least three replicated experiments