TABLE 1.
Baseline characteristics of the MESA sample (N=3,733) and the SPRINT-eligible subsample (N= 1,394), according to baseline blood pressure (BP) therapy
| MESA Study Sample | P-value* | Sprint-Eligible Subsample | P-value* | |||
|---|---|---|---|---|---|---|
| No BP Therapy (N= 1964) | BP Therapy (N= 1769) | No BP Therapy (N= 613) | BP Therapy (N= 781) | |||
| Age, years | 63.4 (±9.9) | 66.1 (±9.3) | <0.001 | 69.0 (±7.9) | 69.4 (±7.8) | 0.51 |
| Male | 1004 (51) | 796 (45) | <0.001 | 412 (67) | 401 (51) | <0.001 |
| Race | <0.001 | <0.001 | ||||
| White | 757 (38) | 548 (31) | 253 (41) | 280 (36) | ||
| Black | 505 (26) | 700 (40) | 148 (24) | 278 (36) | ||
| Hispanic | 464 (24) | 349 (20) | 139 (23) | 146 (19) | ||
| Chinese | 238 (12) | 172 (10) | 73 (12) | 77 (10) | ||
| Body Mass Index, kg/m2 | 28.3 (±5.3) | 29.8 (±5.6) | <0.001 | 27.7 (±4.6) | 28.8 (±5.32) | <0.001 |
| Systolic BP, mmHg | 137.2 (±13.4) | 141.2 (±14.1) | <0.001 | 147.2 (±12.3) | 148.4 (±12.2) | 0.035 |
| Diastolic BP, mmHg | 76.2 (±8.8) | 75.6 (±9.5) | 0.02 | 78.5 (±9.0) | 77.6 (±9.6) | 0.17 |
| Fasting Glucose, mg/dL | 97.0 (±30.7) | 103.8 (±33.0) | <0.001 | 92.1 (±10.5) | 93.7 (±11.4) | 0.01 |
| Diabetes | 174 (9) | 385 (22) | <0.001 | - | - | |
| Smoking Status | <0.001 | <0.001 | ||||
| Current Smoker | 269 (14) | 167 (9) | 88 (14) | 80 (10) | ||
| Never Smoker | 942 (48) | 932 (53) | 249 (40) | 391 (50) | ||
| Former Smoker | 747 (38) | 661 (38) | 273 (45) | 306 (40) | ||
| LDL-C, mg/dL | 120.8 (±30.9) | 113.4 (±31.1) | <0.001 | 125.1 (±30.8) | 116.7 (±30.9) | <0.001 |
| HDL-C, mg/dL | 51.2 (±14.9) | 50.4 (±14.1) | 0.18 | 48.8 (±14.2) | 50.7 (±14.3) | <0.005 |
| Triglycerides, mg/dL | 116 (79-164) | 113 (81-166) | 0.92 | 122 (87-166) | 113 (83-165) | 0.12 |
| Creatinine, mg/dL | 0.94 (±0.21) | 1.0 (±0.29) | <0.001 | 1.01 (±0.22) | 1.04 (±0.28) | 0.07 |
| Family History of MI | 771 (42) | 801 (49) | <0.001 | 238 (43) | 359 (50) | 0.001 |
| 10 year ASCVD Risk, % | 14 (±11) | 22 (±0.15) | <0.001 | 21 (±22) | 24 (±12) | <0.001 |
| ASCVD Risk Score Categories | <0.001 | <0.001 | ||||
| <7.5% | 683 (35) | 276 (16) | 23 (4) | 29 (4) | ||
| 7.5-15% | 552 (28) | 402 (23) | 192 (32) | 160 (21) | ||
| >15% | 716 (37) | 1072 (61) | 393 (65) | 584 (75) | ||
Values are for number (%), median (IQR) or mean (±SD)
*
P values are for differences between groups using 1-way ANOVA, Kruskal Wallis testing, or χ2, as appropriate.
ASCVD indicates atherosclerotic cardiovascular disease; BP, blood pressure; HDL-C, high-density lipoprotein-cholesterol; LDL-C, low-density lipoprotein-cholesterol; MESA, multi-ethnic study of atherosclerosis; and MI, myocardial infarction.