Table 1.
Increased hepatic miRNA expression in vaccinated mice infected with P. chabaudi on day 11 p.i. (Vd11) compared to non-vaccinated mice infected with P. chabaudi on day 11 p.i. (Nd11).
| miRNA name | % increase Vd11 vs. Nd11 | Function | PMID |
|---|---|---|---|
| let-7a | +50 | Up-regulated during early phase of liver regeneration | 21574170, 18812516 |
| let-7b | +50 | Up-regulated during early phase of liver regeneration | 21574170, 18812516 |
| let-7c | +50 | Up-regulated during early phase of liver regeneration | 21574170, 18812516 |
| let-7d | +51 | Up-regulated during early phase of liver regeneration | 21574170, 18812516 |
| let-7f | +51 | Up-regulated during early phase of liver regeneration | 21574170, 18812516 |
| let-7g | +51 | Up-regulated during early phase of liver regeneration | 21574170, 18812516 |
| let-7i | +57 | Up-regulated during early phase of liver regeneration | 21574170, 18812516 |
| miR-122-5p | +60 | Abundantly expressed in liver; involved in cholesterol biosynthesis pathway; binds to the HCV genome and enhances viral translation and replication | 16258535,25574453, 16141076 |
| miR-142-3p | +121 | Orchestrates network of actin cytoskeleton during megakaryopiesis | 24859754 |
| miR-148a-3p | +81 | miR-148a-3p downregulates Met/Snail signaling pathway and thus inhibits the epithelial to mesenchymal transition (EMT) | 23532995 |
| miR-26a-5p | +63 | Involved in liver regeneration and hepatocyte proliferation; miR-26a expression reduced M-CSF expression and recruitment of macrophages in HCC | 26818545, 26021873 |
| miR-27a-3p | +71 | Involved in lung fibrosis | 26600197 |
| miR-29b-3p | +61 | Members of the miR-29 family are downregulated in HSCs in response to TNF and TGF-β signaling and suppress the transcription of ECM genes like collagen-1α1 | 20890893 |
| miR-2861 | +52 | Important physiological role in osteoblast differentiation and contributes to osteoporosis via its effect on osteoblasts | 19920351 |
| miR-30a-5p | +52 | Members of a network of miRNAs modifying the TGF-β-dependent regulation of extracellular matrix-related genes in HSCs in the manifestation and resolution of liver fibrosis | 26120970 |
| miR-30c-5p | +127 | Members of a network of miRNAs modifying the TGF-β-dependent regulation of extracellular matrix-related genes in HSCs in the manifestation and resolution of liver fibrosis | 26120970 |
| miR-3968 | +96 | Unknown | |
| miR-5097 | +98 | Unknown |