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. 2017 Jan 11;7:690. doi: 10.3389/fimmu.2016.00690

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Copyright © 2017 Jiang, Jiang, Chen, Lai, Wei, Li, Lin, Wang, Wu, Liang, Liu, Peng, Yu, Weng, Du, Pei, Liu, Yao, Xue and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cytotoxicity of glypican 3 (GPC3)-chimeric antigen receptor (CAR) T cells against hepatocellular carcinoma cell lines in xenografts. (A,B) Growth curve of Huh-7 and HepG2 xenografts (n = 5) treated with the Control- or GPC3-CAR T cells at indicated time point (arrow). At the end of the experiment, the tumors treated with GPC3-CAR T cells were significantly smaller than those in the Control group. (C,D) Huh-7 and HepG2 tumor weights from the mice treated with CAR T cells at the end of the experiment, respectively. (E,F) GPC3-CAR T cells in tumors were significantly higher than Control-CAR T groups. Results represent mean ± SD. *P < 0.05, **P < 0.01, and ***P < 0.001 with T-test.