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. 2017 Jan 11;7:692. doi: 10.3389/fimmu.2016.00692

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Copyright © 2017 Ogbomo and Mody.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Natural killer (NK) cell/tumor cytotoxicity pathway. Following receptor–ligand interaction, NK cell receptors initiate multiple signaling cascades. While the natural cytotoxic receptors (NKp30, NKp44, and NKp46) signal through Src family kinase (SFK) to activate PI3K/Rac/Erk pathway, DNAM-1 and 2B4 signal SFK to activate Rac/Erk pathway, thereby leading to cytotoxicity.