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U0126, SP600125 reverse the effect of NE on MMP-9 expression in LPS-Challenged THP-1 cells
After being pre-treated with U0126, SP600125, SB203580, or a vehicle for 30 min, THP-1 cells were stimulated with NE for 40 min, and then with LPS for another 48 h (A) (B) (C). MMP-9 level and enzyme activity were detected by ELISA kit (A) and zymography (B) (C). *P < 0.05, **P < 0.01. ***P < 0.001
