Table 6. AASLD-IDSA recommendations for patients who would receive the most immediate benefits from treatment.

Highest-priority for treatment owing to highest risk for severe complications	High-priority for treatment owing to high risk for complications
Advanced fibrosis (METAVIR F3) or compensated (METAVIR F4)	Fibrosis (METAVIR F2)
Organ transplant recipients	HIV-1 coinfection
Type 2 or 3 cryoglobulinemia with end-organ manifestations (e.g., vasculitis)	Hepatitis B virus coinfection
Proteinuria, nephrotic syndrome or membranoproliferative glomerulonephritis	Other coexistent liver disease (e.g., nonalcoholic steatohepatitis)
	Debilitating fatigue
	Type 2 Diabetes mellitus (insulin-resistant)
	Porphyria cutanea tarda

Abbreviation: HIV, Human immunodeficiency virus.