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. 2016 May 5;91(1):289–300. doi: 10.1007/s00204-016-1725-8

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — a Median loss of TL in the peripheral blood of PCB-exposed individuals measured by flow-FISH. TL is expressed as age-adjusted telomere length (∆Tel) and was calculated based on the TL of 104 unexposed individuals reported on previously. b Mean ± SD ∆Tel of lymphocytes for individual indicator PCBs depending on plasma concentration. Lower and higher concentrated plasma PCB levels were separated using the median value as cutoff. c Total lymphocyte numbers as determined by automated blood counting according to plasma levels of lower chlorinated PCBs. Lower and higher concentrated plasma PCB levels were split at the median. d Correlation between T cell receptor excision circle (TREC) levels in peripheral blood CD3+ T cells and the sum of PCBs (including lower chlorinated, higher chlorinated and dioxin-like PCBs). e Negative correlation between TREC levels and age of exposed individuals. Statistically significant differences are indicated (*p < 0.05; ***p < 0.001)