Table 3.

Top 20 most inducible by BNF treatment and AhR-dependent genes as determined by microarray-based gene expression analysis in HepaRG undifferentiated cells

Gene (symbol)	Accession No.	BNF induction (contr.BNF/contr. DMSO)		AhR knockdown (AhR(−) BNF/contr. BNF)
		Fold-change	P value	Fold-change	P value
CYP1A1	NM_000499	84.4479	1.96E-09	−2.26041	4.43E-05
SERPINB2	NM_002575	38.9277	5.37E-10	−1.74217	3.88E-05
TMEM156	NM_024943	17.0552	1.31E-06	−4.25365	6.58E-05
CYP1B1	NM_000104	9.99312	6.71E-06	−4.8724	0.000114
TIPARP	NM_015508	9.97469	6.29E-07	−3.38236	2.62E-05
TAC1	NM_003182	7.52859	2.97E-06	−5.1163	1.03E-05
SLC7A11	NM_014331	6.84783	9.66E-07	−1.89915	0.000527
SLC7A5	NM_003486	6.65738	3.53E-06	−5.4473	6.80E-06
IGFBP1	NM_000596	6.23676	7.86E-08	−1.89982	3.77E-05
SCG5	NM_003020	5.92127	5.02E-06	−5.22126	7.71E-06
SLC37A2	NM_198277	5.91685	2.40E-06	−2.79372	5.83E-05
AMIGO2	NM_181847	5.36008	1.15E-05	−3.69017	4.90E-05
SLC14A1	NM_015865	5.29511	1.02E-05	−17.1535	4.38E-07
EREG	NM_001432	4.41706	2.30E-05	−1.89436	0.002332
ARL4C	NM_005737	3.87399	3.59E-07	−1.30965	0.003173
PXK	NM_017771	3.8716	1.52E-07	−2.37851	2.14E-06
HMGA2	NM_003484	3.81293	1.82E-07	−1.44529	0.000326
HK2	NM_000189	3.63351	4.47E-05	−2.41403	0.000378
STC2	NM_003714	3.52418	8.44E-07	−1.67544	0.00015
KYNU	NM_003937	3.39497	2.82E-06	−1.89998	0.000117

Information of all additional genes out of top 20 is available in the supplementary material accompanying of the manuscript (Supplementary 2—induction)

Fold-change value that was less than 1 has been replaced by the negative of its inverse (for example, 0.1 was replaced by −10)

Contr. HepaRG cells transfected with control plasmid, AhR ⁻ HepaRG cells transfected with plasmid knocking down Ah receptor