Table 5.

Top 20 most inhibited by BNF treatment and AhR-dependent genes as determined by microarray-based gene expression analysis in HepaRG undifferentiated cells

Gene (symbol)	Accession No.	BNF repression (contr.BNF/contr. DMSO)		AhR knockdown (AhR(−) BNF/contr. BNF)
		Fold-change	P value	Fold-change	P value
KIAA1456	NM_020844	−4.45339	9.35E-05	2.06645	4.25E-03
KDR	NM_002253	−4.13891	4.18E-06	1.5346	3.18E-03
FGG	NM_021870	−3.98685	9.06E-07	2.38767	1.38E-05
ART3	NM_001179	−3.83642	1.48E-06	9.44067	7.00E-08
KCNB1	NM_004975	−3.65479	1.44E-05	3.2784	2.39E-05
FAM65B	NM_014722	−3.559	1.79E-04	2.76605	5.99E-04
PLCL1	NM_006226	−3.51205	7.21E-05	1.60191	1.12E-02
MLIP	NM_138569	−3.50818	3.56E-07	3.30055	4.79E-07
PPL	NM_002705	−3.47763	4.52E-05	4.68824	1.31E-05
MCF2	NM_005369	−3.44442	1.67E-05	1.81629	9.73E-04
CIDEC	NM_022094	−3.39535	5.04E-06	2.71645	1.63E-05
PDE1A	NM_005019	−3.35762	5.66E-05	3.50297	4.65E-05
CIDEC	NM_022094	−3.32232	2.55E-05	2.76084	6.65E-05
PLCL1	NM_006226	−3.24423	8.63E-05	1.54723	0.013509
SAA2	NM_030754	−3.19599	0.003267	3.18935	0.003296
NRXN3	NM_004796	−3.15472	1.60E-05	4.53509	3.21E-06
MUM1L1	NM_152423	−3.14915	6.06E-06	1.81139	0.000261
FLRT3	NM_013281	−3.14526	2.78E-06	2.13495	3.09E-05
SORBS1	NM_006434	−3.11927	0.000186	2.49061	0.000621
FABP4	NM_001442	−3.0878	1.80E-05	25.5207	3.50E-08

Information of all additional genes out of top 20 is available in the supplementary material accompanying of the manuscript (Supplementary 3—inhibition)

Fold-change value that was less than 1 has been replaced by the negative of its inverse (for example, 0.1 was replaced by −10)

Contr. HepaRG cells transfected with control plasmid, AhR ⁻ HepaRG cells transfected with plasmid knocking down Ah receptor