Table 6.

Top 20 most inhibited by BNF treatment and AhR-dependent genes as determined by microarray-based gene expression analysis in HepaRG differentiated cells

Gene (symbol)	Accession No.	BNF repression (contr.BNF/contr. DMSO)		AhR knock down (AhR(−) BNF/contr. BNF)
		Fold-change	P value	Fold-change	P value
CYP4F3	NM_000896	−3.44897	6.68E-05	1.91091	0.002218
ABCD2	NM_005164	−3.3931	2.81E-06	3.16358	3.98E-06
GSTA2	NM_000846	−3.2792	0.00027	2.57352	0.000923
PPL	NM_002705	−3.15243	7.22E-05	5.03675	1.00E-05
LIFR	NM_002310	−3.12767	0.000326	2.07572	0.003313
GSTA1	NM_145740	−3.1041	6.89E-06	1.97077	0.000131
SLC38A4	NM_018018	−3.01334	3.39E-05	1.53637	0.005241
SPP1	NM_000582	−2.98976	2.13E-05	1.7532	0.000884
PDZK1	NM_002614	−2.90891	4.81E-06	1.36698	0.004118
FAM65B	NM_014722	−2.85695	0.000506	5.59945	3.16E-05
MCF2	NM_005369	−2.74897	1.15E-05	3.97328	1.85E-06
CTGF	NM_001901	−2.64531	9.64E-06	3.91883	1.31E-06
PLAC8	NM_016619	−2.59761	5.42E-05	1.49609	0.005266
CALCR	NM_001742	−2.59678	1.42E-05	1.38406	0.004838
AKR1B10	NM_020299	−2.59623	5.78E-05	21.371	6.06E-08
CYP3A4	NM_017460	−2.58788	0.000534	1.83438	0.005209
SEMA3C	NM_006379	−2.57786	0.001181	1.74833	0.014406
RDH5	NM_002905	−2.54186	1.26E-05	12.5243	3.45E-08
PKP2	NM_004572	−2.53416	0.000395	1.63935	0.009291
KCNB1	NM_004975	−2.50343	0.000104	3.24028	2.54E-05

Information of all additional genes out of top 20 is available in the supplementary material accompanying of the manuscript (Supplementary 3—inhibition)

Fold-change value that was less than 1 has been replaced by the negative of its inverse (for example, 0.1 was replaced by −10)

Contr. HepaRG cells transfected with control plasmid, AhR(−) HepaRG cells transfected with plasmid knocking down Ah receptor