Table 7.
Cell differentiation-dependent effects of AhR silencing and BNF treatment on mRNA expression of CCNE2 and IL8 genes
| Cell types | Probe set ID. | BNF induction (contr.BNF/contr. DMSO) | AhR knockdown (AhR(−)BNF/contr. BNF) | ||
|---|---|---|---|---|---|
| Fold-change | P value | Fold-change | P value | ||
| CCNE2 (NM_057749) | |||||
| HepaRG undifferentiated | 11728300_at | 4.55583 | 1.77E-06 | 2.38103 | 4.59E-05 |
| 11728301_at | 2.60968 | 2.54E-05 | 2.08231 | 0.000117 | |
| HepaRG differentiated | 11728300_at | 1.37344 | 0.008872 | −1.57768 | 0.001553 |
| 11728301_at | 1.11149 | 0.250375 | −1.30069 | 0.019462 | |
| IL8 (NM_000584) | |||||
| HepaRG undifferentiated | 11718841_s_at | 3.3702 | 3.39E-06 | 1.35246 | 0.006721 |
| 11754026_a_at | 5.29994 | 0.000192 | 1.60235 | 0.062341 | |
| 11763226_x_at | 3.64619 | 1.85E-05 | 1.56707 | 0.005473 | |
| HepaRG differentiated | 11718841_s_at | 2.47773 | 1.87E-05 | −1.80874 | 0.000211 |
| 11754026_a_at | 2.30724 | 0.006706 | −1.7321 | 0.037385 | |
| 11763226_x_at | 1.6419 | 0.003416 | −1.53201 | 0.006949 | |