Table 1.
Hematological and hemorheological parameters in SCD patients (SCA + SCC) categorized according to retinopathy severity
| Group 1 (n=17) | Group 2 (n=24) | Group 3 (n=18) | |
|---|---|---|---|
| Leukocytes (109/l) | 7.55 ± 1.90 | 9.42 ± 3.10 | 8.73 ± 2.61 |
| RBCs (1012/l) | 3.58 ± 0.88 | 3.36 ± 1.05 | 3.56 ± 0.81 |
| Hb (g/100 ml) | 9.74 ± 1.80 | 9.40 ± 2.08 | 10.04 ± 1.28 |
| MCV (fl) | 77.95 ± 10.85 | 79.42 ± 9.07 | 79.83 ± 10.52 |
| MCH (pg) | 27.92 ± 4.27 | 28.80 ± 3.44 | 28.96 ± 3.88 |
| Platelets count (109/l) | 351.88 ± 124.99 | 299.88 ± 135.26 | 416.72 ± 149.62 † |
| Polynuclear Neutrophils (109/l) | 3.67 ± 1.15 | 5.04 ± 1.90 | 4.80 ± 2.21 |
| Eosinophils (109/l) | 0.31 ± 0.26 | 0.28 ± 0.21 | 0.26 ± 0.15 |
| Lymphocytes (109/l) | 2.67 ± 0.66 | 2.93 ± 1.21 | 2.77 ± 1.00 |
| Monocytes (109/l) | 0.85 ± 0.37 | 1.11 ± 0.63 | 0.83 ± 0.37 |
| Reticulocytes (%) | 5.02 ± 2.80 | 5.80 ± 3.37 | 5.10 ± 3.57 |
| Lactate dehydrogenase (UI/l) | 359.94 ± 120.47 | 447.60 ± 147.44 | 348.47 ± 115.49 |
| Hct (%) | 29.54 ± 4.89 | 28.53 ± 6.24 | 28.94 ± 4.52 |
| ηb at 90s−1(mPa/s | 8.31 ± 2.28 | 7.86 ± 2.01 | 8.98 ± 2.21 |
| EI at 0.95 Pa | 0.06 ± 0.03 | 0.06 ± 0.04 | 0.07 ± 0.03 |
| EI at 1.69 Pa | 0.12 ± 0.03 | 0.10 ± 0.04 | 0.12 ± 0.03 |
| EI at 3 Pa | 0.19 ± 0.04 | 0.16 ± 0.05 | 0.17 ± 0.04 |
| EI at 5.33 Pa | 0.26 ± 0.05 | 0.22 ± 0.07 | 0.23 ± 0.06 |
| EI at 9.49 Pa | 0.33 ± 0.06 | 0.29 ± 0.08 | 0.30 ± 0.07 |
| EI at 16.87 Pa | 0.39 ± 0.07 | 0.34 ± 0.09 | 0.36 ± 0.08 |
| EI at 30 Pa | 0.43 ± 0.08 | 0.38 ± 0.10 | 0.40 ± 0.08 |
| AI (%) | 52.78 ± 10.05 | 50.88 ± 8.41 | 49.58 ± 9.24 |
| γthr (s−1) | 242.94 ± 74.69 | 277.41 ± 117.25 | 309.62 ± 173.74 |
Group 1: without sickle cell retinopathy, group 2: non-proliferative and proliferative stage I and II retinopathy, group 3: proliferative retinopathy of stage III, IV and V. Mean ± SD. RBCs = red blood cells, Hb = hemoglobin concentration, MCV = mean corpuscular volume, MCH = mean corpuscular hemoglobin, Hct = hematocrit, ηb = whole blood viscosity, EI = Elongation Index (i.e. RBC deformability), AI = RBC aggregation index, γthr = RBC disaggregation threshold.
†
Different from group 2 (p < 0.05).