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. 2016 Dec;186(12):3131–3145. doi: 10.1016/j.ajpath.2016.08.021

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© 2016 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

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Prostate cancer is characterized by direct correlation between the expression of polyamine pathway enzymes and inverse correlation of these enzymes with spermine abundance. A–D: Representative immunofluorescence analysis of PA pathway enzymes' expression and spermine abundance in prostate cancer (PCa) and high-grade prostatic intraepithelial neoplasia [HGPIN; ornithine decarboxylase (ODC) and spermine in A and D; polyamine oxidase (PAO) and spermine synthase (SPSY) in B and C]. Scale bars = 100 μm (A–D). PA, polyamine.