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Evidence of type IV hypersensitivity mechanisms in the pituitary gland of the autopsy case. A: Diffuse infiltration of the anterior pituitary with lymphocytes. Lymphocytes are CD4-positive T cells (B) and CD20-positive B cells (C). D: Lymphocytes intimately contact the pituitary acidophil cells (arrows), and in some cases penetrate in their cytosol (arrowhead). Scale bars: 50 μm (A); 100 μm (B and C); 20 μm (D). Original magnification: ×64 (A); ×40 (B and C); ×260 (D).
