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. 2017 Jan;19(1):57–64. doi: 10.1016/j.jmoldx.2016.07.008

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© 2017 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.

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Differences in colorectal cancer (CRC) and endometrioid cancer (EMC) nucleotide shifts observed in microsatellite instability (MSI) profiles. A: Alterations in repeat length for all loci in all MSI-high CRC (cyan; n = 46) and EMC (magenta; n = 20) are plotted in the graph. B: Alterations in repeat length in five individual mononucleotide markers are plotted in the graph. C: The distribution of mean absolute shifts in repeat lengths of five markers per tumor differs significantly between CRC (cyan) and EMC (magenta). The mean nucleotide shifts in EMC (magenta) are significantly smaller than those of CRC (cyan) in all markers. P < 0.0001.