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. 2017 Jan;187(1):187–199. doi: 10.1016/j.ajpath.2016.09.002

Figure 1.

Figure 1

Salmonella infection and dissemination in Nramp1−/− and Nramp1+/+ mice. A: Organ colonization of Nramp1−/− mice with clinical salmonellosis. Mice were infected orally with 104, 106, 107, or 108Salmonella. Samples were collected on development of clinical disease, up to 10 days postinfection (dpi). B: Percentage survival of Nramp1−/− and Nramp1+/+ mice infected with 108 or 109 colony-forming units (CFUs) Salmonella, respectively. C: Bacterial loads in Nramp1−/− mice infected with 108Salmonella. D: Bacterial loads in Nramp1+/+ mice infected with 109Salmonella. Mice with clinical ataxia or rolling disease are shown separately. E and F: Relationship between bacterial loads in the blood and brain of Nramp1−/− (E) or Nramp1+/+ (F) mice at 6 or 21 days postinfection. Data were fitted using a linear regression model of transformed log-log CFU data. Mice with ataxia are indicated. Data represent means ± SD (C and D). n = 3 (A, 104 and 107Salmonella); n = 2 (A, 106 and 108Salmonella); n = 50 (B, Nramp1−/−); n = 54 (B, Nramp1+/+); n = 3 to 14 mice per time point (C); n = 2 to 20 mice per time point (D).