Figure 8.

Neutrophil infiltration, focal hemorrhaging, and ventriculitis in the brains of ataxic Nramp1^+/+ mice. Brains from mice with clinical signs of ataxia after infection with Salmonella were stained with hematoxylin and eosin. A: Low-magnification image showing neutrophil infiltration and hemorrhaging (boxed area), magnified in B. Malacia with neutrophil infiltrate and focal hemorrhaging in the corpus callosum (B and C) and lateral ventricle (D). E: Image of hippocampus and corpus callosum from an uninfected mouse for comparison. F and G: Infiltration and vascular thrombosis. Black arrowheads indicate regions of hemorrhage; yellow arrowheads, regions of tissue clearing; and white arrowheads, regions of cellular infiltrate. Scale bars: 2 mm (A); 200 μm (B); 500 μm (C–E); 50 μm (F and G).