Table 1.

Tumor DNA Computational Purity, DNA Indices, and Centromeric FISH Analysis of a Cohort of 17 MSS Colorectal Adenocarcinomas

Sample	Purity	DNA Index	Chr2			Chr15			Ploidyc
			Mode (%MCD)a		p Valueb	Mode (%MCD)a		p Valueb
			Normal	Tumor		Normal	Tumor
389	0.42	1.58	2 (41)	1 (60)	0.006	2 (39)	1 (61)	5 × 10−4	A
363	0.69	2.23	2 (39)	3 (74)	5 × 10−4	2 (32)	2 (65)	5 × 10−4	A
391	0.48	1.59	2 (37)	2 (60)	5 × 10−4	2 (38)	1 (64)	0.005	A
377	0.40	1.5	2 (42)	3 (60)	5 × 10−4	2 (45)	3 (57)	5 × 10−4	A
361	0.8	1.27	2 (43)	1 (64)	5 × 10−4	2 (30)	2 (54)	0.01	A
379	0.36	1.63	2 (39)	4 (74)	5 × 10−4	2 (31)	2 (53)	0.03	A
367	0.21	1.42	2 (36)	3 (56)	5 × 10−4	2 (41)	2 (56)	0.1	A
369	0.48	1.61	2 (37)	3 (69)	5 × 10−4	2 (38)	3 (55)	5 × 10−4	A
365	0.18	1.49	2 (33)	2 (53)	0.002	2 (39)	3 (53)	5 × 10−4	A
395	0.42	1	2 (47)	2 (55)	0.12	2 (43)	1 (42)	5 × 10−4	A
375	0.35	1	2 (37)	2 (33)	0.14	2 (34)	2 (32)	0.25	D
397	0.49	1	2 (36)	2 (41)	0.18	2 (37)	2 (32)	0.25	D
385	0.56	1	2 (41)	2 (34)	0.22	2 (35)	2 (29)	0.22	D
381	0.63	1	2 (37)	2 (37)	0.4	2 (30)	2 (24)	0.05	D
383	0.47	1	2 (39)	2 (48)	0.5	2 (32)	2 (35)	0.22	D
373	0.65	1	2 (47)	2 (51)	0.7	2 (48)	2 (55)	0.19	D
371	0.35	1	2 (39)	2 (33)	0.12	2 (45)	2 (35)	0.19	D

See also Figures S1 and S2; Table S1.

^aPercentage modal centromeric deviation.

^bNormal-tumor comparison (two-tailed Fisher's exact test and Monte Carlo simulations).

^cA = aneuploid; D = diploid.