Figure 2. Representative histology with H&E (hematoxylin and eosin staining) at 100x magnification from 24-week-old mice in the moribund stage after C. neoformans administration.

Cryptococcoma-like lesions were observed only in the brains of FcγRIIb+/+ mice (left column). In FcγRIIb−/− mice (right column), several internal organs had cryptococcoma-like lesions (brain, kidneys, liver, lung and spleen).