Table 2. Biological data and univariate analysis of overall survival (the cut-off was the median value of each marker or twice the upper limit of normal when specified).
| Median (range) | Median OS, months (95% CI) | P value | |
|---|---|---|---|
| CgA, μg/L (n = 44) | 156.5 (20.0–11192.0) | — | 0.64 |
| CgA < 2 ULNa | 26 (59) | 16 (14.1–17.9) | 0.85 |
| CgA ≥ 2 ULNa | 18 (41) | 14 (9.4–18.6) | |
| NSE, μg/L (n = 44) | 34.1 (6.6–956.1) | 0.12 | |
| NSE < 2 ULNa | 18 (41) | 17 (13.6–20.4) | 0.13 |
| NSE ≥ 2 ULNa | 26 (59) | 13 (8.1–17.9) | |
| LDH, IU/L (n = 52) | 338 (130–2722) | — | 0.33 |
| LDH < 2 ULNa | 37 (71) | 19 (13.4–24.6) | <0.001 |
| LDH ≥ 2 ULNa | 15 (29) | 9 (8.0–10.0) | |
| ALP, IU/L (n = 59) | 141 (30–2362) | — | 0.64 |
| ALT, IU/L (n = 58) | 29 (6–487) | — | 0.55 |
| AST, IU/L (n = 61) | 29.5 (7.0–376.0) | — | 0.58 |
| AST < 2 ULNa | 42 (69) | 18 (13.1–22.9) | 0.001 |
| AST ≥ 2 ULNa | 19 (31) | 8 (0.9–15.1) | |
| Total bilirubin, μmol/L (n = 58) | 9.5 (2.0–493.0) | — | 0.74 |
| Albumin, g/L (n = 52) | 37.9 (20.3–45.0) | — | 0.58 |
| CRP, mg/L (n = 53) | 18.9 (0.6–224.5) | — | 0.29 |
| Fibrinogen, g/L (n = 53) | 4.5 (1.9–7.4) | — | 0.24 |
| PT, % (n = 55) | 96 (20–111) | — | 0.29 |
| aPTT, ratio (n = 47) | 1.0 (0.8–3.9) | — | 0.87 |
| Hb, g/L (n = 63) | 126.0 (49.1–159.0) | — | 0.86 |
| Leukocytes, G/L (n = 63) | 7.4 (2.1–27.2) | — | 0.66 |
| Lymphocytes, G/L (n = 61) | 1.5 (0.5–6.0) | — | 0.10 |
| Neutrophils, G/L (n = 61) | 5.5 (0.4–23.9) | — | 0.85 |
| Neutrophil/Lymphocyte ratio (n = 61) | 3.6 (0.2–21.7) | — | 0.16 |
| NLR < 3a | 23 (38) | 16 (8.0–24.0) | 0.35 |
| NLR ≥ 3a | 38 (62) | 16 (13.5–18.5) | |
| NLR < 4a | 34 (56) | 16 (7.7–24.3) | 0.06 |
| NLR ≥ 4a | 27 (44) | 16 (13.2–18.8) | |
| Platelets, G/L (n = 63) | 273 (81–816) | 0.85 |
Abbreviations: aPTT, activated partial thromboplastin time; AST, aspartate aminotransferase; ALP, alkaline phosphatase; ALT, alanin aminotransferase; CgA, chromogranin A; CI, confidence interval; CRP, C-reactive protein; Hb, hemoglobin; LDH, lactate dehydrogenase; NLR, neutrophil-to-lymphocyte ratio; NSE, Neuron-specific enolase; OS, overall survival; PT, prothrombin time, ULN, upper limit of normal; Notes: an (%).