Figure 2. IVIg blocks SE-induced BBB breakdown.

Representative images from Evans Blue dye experiments showing superior and inferior (basal) views of the brain (top and middle rows) as well as coronal sections (bottom row) for sham and ‘no SE’ controls, or SE mice that were post-treated with either vehicle or IVIg. Note that the prominent SE-induced breakdown of the blood-brain barrier (BBB), as evident from the extravasation of Evans Blue dye into the hippocampus, amygdala and piriform cortex, is attenuated by IVIg treatment.