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. 2017 Jan 11;7:40413. doi: 10.1038/srep40413

Figure 1. Screen for miRNAs regulated by chronic heroin administration.

Figure 1

(a) Identification of addiction-related miRNA candidates. Network propagation based method (NP method) was used to predict potentially perturbed miRNAs in addiction-related process. Based on significance of NPES score, 40 miRNA families (45 miRNAs) were identified as putative candidates. (b) Heatmap of differentially expressed miRNAs in microarray. Rats were treated with saline or heroin (1 mg/kg, i.p., b.i.d.) for 7 days. MiRNAs that exhibit ≥25% alterations were shown. (c) NP method-based prediction and altered miRNAs in response to chronic heroin exposure was collapsed, resulting in 16 intersected miRNAs. (d) Heatmap of the 16 intersected miRNAs arranged by prediction scores (CS, Chronic Saline; CH, Chronic Heroin).