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. 2017 Jan 11;7:40413. doi: 10.1038/srep40413

Figure 4. MiR-218 inhibits heroin seeking behavior.

Figure 4

(a) CPP score of LV-control and LV-miR-218 group in pre-test and test session. Rats were subjected to LV-control or LV-miR-218 injection. Seven days later, they were subjected to pre-test, three conditioning sessions and CPP test. Heroin induced CPP is decreased in LV-miR-218 group (LV-control, n = 10, LV-miR-218, n = 9, **P < 0.01 vs. LV control during test session). (b) Lever presses of LV-control and LV-miR-218 rats in heroin self-administration. Rats were subjected to heroin self-administration procedure for eight days and then randomly grouped to receive NAc LV-control or LV-miR-218 injection. Three days later, daily SA sessions were resumed. LV-miR-218 group showed decreased heroin consumption after lentivirus injection (LV-control, n = 6, LV-miR-218, n = 9, Two-way RM ANOVA. *P < 0.05 vs. LV-control on the same day). Data are shown as mean ± s.e.m.