Figure 5. Transmembrane region and part of the C-linker of two neighboring subunits of HCN4 (white and gray).

The contacts that cause significant change of displacement when switched off are indicated by cylinders. Intra-subunit contacts are drawn in red (282–295, 269–309, 322–334, 286–381, 266–396, 266–399, 395–407, 395–408, 402–560, 403–561), inter-subunit contacts in yellow (430–277, 466–278, 466–282, 438–284, 438–286, 424–407, 497–422, 331–545).