Table 3. The chronological metabolic events for the progression to postoperative lung injury.

Metabolites	Pre-CPB	Post-CPB (0 hour)	2 hours	4 hours	8 hours	20 hours
Trigonelline	√	√	√	√	√	√
3-Methylhistidine	√	√	√	√	√	√
Glycine	√	√	√	√	√	√
Inosine	√	√	√	√	√	√
Tyrosine	√	√	√	√	√	√
Dopa	√	√	√	√	√	√
Isobutyrylglycine	√	√	√	√	√	√
Malonate	√	√	√	√	√	√
Monounsaturated fatty acids (MUFA)		√		√	√	√
Free fatty acids				√	√	√
Polyunsaturated fatty acid (PUFA)		√	√	√	√	√
Glycerol		√	√
Lipoproteins		√	√	√	√	√
Cholesterol		√		√	√	√
Phosphatidylcholine		√	√	√	√
Choline		√	√	√
Hypoxanthine		√	√	√	√	√
Xanthine		√	√	√	√	√
1-Methylhistidine		√	√
Uric acid		√	√	√	√	√
Isoleucine		√	√			√
Leucine		√		√	√	√
Glutamate		√	√
Alanine		√	√	√	√	√
Pyruvate		√	√	√	√	√
Citrate		√	√	√	√	√
N-Acetyl-Galactosamine (N-Ac-Gal)		√	√			√
3-Hydroxybutyric acid (3-HBA)		√		√	√
Acetoacetic acid		√		√	√
Acetate			√	√	√	√
Acetone			√	√	√	√
Triacylglycerol (TAG)				√	√	√
N-Acetyl-Glucosamine (N-Ac-Glc)						√

Annotation: ‘√’, the time point at which a metabolite was found to differ between patients.