Table 2.
Top 15 transcription factors enriched in MDA-MB-231 cells
| TF name | Motif | Selection by: | TF binding sites | Ref. sites | Expected sites in ref. | Ratio of enrichment | Mean read count |
|---|---|---|---|---|---|---|---|
| MYBL2 | MYBB_f1 | 2, 3, 4 | 12 | 2930 | 6.2 | 1.92 | 2197 |
| BACH1 | BACH1_si | 1, 2, 3 | 15 | 3904 | 8.3 | 1.81 | 531 |
| MYC | MYC_f1 | 1, 2, 4 | 10 | 2698 | 5.7 | 1.74 | 3044 |
| MAFK | MAFK_si | 2, 3 | 16 | 4428 | 9.4 | 1.70 | 688 |
| RELA | TF65_f2 | 1, 2, 4 | 19 | 5467 | 11.6 | 1.63 | 1398 |
| PPARA | PPARA_f1 | 1, 2, 3 | 9 | 2747 | 5.8 | 1.54 | 185 |
| NFIA/B/C/X | a | 1, 2, 3 | 15 | 4669 | 9.9 | 1.51 | b |
| NFIL3 | NFIL3_si | 1, 2, 3 | 11 | 3494 | 7.4 | 1.48 | 474 |
| FOXA2 | FOXA2_f1 | 1, 2, 3 | 36 | 11477 | 24.4 | 1.47 | 434 |
| REL | REL_do | 1, 2, 3 | 17 | 5422 | 11.5 | 1.47 | 69 |
| ZFHX3 | ZFHX3_f1 | 2, 3 | 46 | 14683 | 31.2 | 1.47 | 66 |
| RXRB | RXRB_f1 | 1, 2, 4 | 20 | 6414 | 13.6 | 1.47 | 1015 |
| SMARCC1 | SMRC1_f1 | 1, 4 | 20 | 6443 | 13.7 | 1.46 | 1478 |
| ETV5 | ETV5_f1 | 2, 3 | 16 | 5199 | 11.1 | 1.45 | 641 |
| NR3C1 | GCR_si | 1, 2, 4 | 15 | 4910 | 10.4 | 1.44 | 1087 |
The ratio of enrichment is the result of dividing the number of TF binding sites by the number of expected sites. Motifs are derived from the HOCOMOCO database. aNFIA + NFIB + NFIC + NFIX_f2, bRead count range (51, 148, 748, 444, respectively). Ref. reference