Table 3.
Top 15 transcription factors enriched in T-47D cells
| TF name | Motif | Selection by: | TF binding sites | Ref. sites | Expected sites in ref. | Ratio of enrichment | Mean read count |
|---|---|---|---|---|---|---|---|
| MBD2 | MBD2_si | 1, 2, 3, 4 | 101 | 6664 | 39.6 | 2.55 | 571 |
| TFAP2A | AP2A_f2 | 1, 2, 3 | 115 | 10363 | 61.6 | 1.87 | 941 |
| E4F1 | E4F1_f1 | 2, 3 | 18 | 1750 | 10.4 | 1.73 | 310 |
| SP1 | SP1_f1 | 1, 2 | 392 | 41453 | 246.3 | 1.59 | 838 |
| CUX1 | CUX1_f1 | 1, 2, 3 | 13 | 1462 | 8.7 | 1.50 | 141 |
| E2F2 | E2F2_f1 | 1, 2 | 17 | 1941 | 11.5 | 1.47 | 215 |
| AHR | AHR_si | 1, 2, 3 | 9 | 1030 | 6.1 | 1.47 | 791 |
| SP2 | SP2_si | 1, 2 | 140 | 16512 | 98.1 | 1.43 | 672 |
| CREB1 | CREB1_f1 | 1, 2, 3 | 23 | 2720 | 16.2 | 1.42 | 177 |
| CBFB | PEBB_f1 | 1, 2, 3, 4 | 46 | 5461 | 32.4 | 1.42 | 457 |
| ZIC2 | ZIC2_f1 | 1, 2, 3 | 46 | 5487 | 32.6 | 1.41 | 118 |
| ZFX | ZFX_f1 | 1, 2, 3 | 127 | 15650 | 93.0 | 1.37 | 287 |
| HIF1A | HIF1A_si | 1, 2, 3, 4 | 15 | 1890 | 11.2 | 1.34 | 1847 |
| E2F3 | E2F3_si | 1, 2, 3 | 16 | 2019 | 12.0 | 1.33 | 322 |
| XBP1 | XBP1_f1 | 1, 3, 4 | 12 | 1545 | 9.2 | 1.31 | 22744 |
The ratio of enrichment is the result of dividing the number of TF binding sites by the number of expected sites. Motifs are derived from the HOCOMOCO database. Ref. reference