Table 5.
Cox uncensored graft loss, uni- and multivariable model
| Univariable | Multivariable | |||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| TX2 | 1.06 | 0.68-1.67 | 0.789 | 1.24 | 0.77-2.00 | 0.375 |
| Recipient age | 1.07 | 1.04-1.09 | <0.001 | 1.06 | 1.03-1.09 | <0.001 |
| Male recipient | 1.20 | 0.95-1.53 | 0.132 | 1.09 | 0.85-1.40 | 0.510 |
| Coronary heart disease | 1.15 | 0.91-1.45 | 0.247 | |||
| Diabetes mellitusa | 1.21 | 0.93-1.57 | 0.160 | 1.08 | 0.80-1.45 | 0.607 |
| Cerebrovascular disease | 1.27 | 0.92-1.75 | 0.143 | 1.14 | 0.81-1.59 | 0.462 |
| Peripheral vascular disease | 1.23 | 0.96-1.58 | 0.106 | 0.97 | 0.74-1.28 | 0.840 |
| Time on dialysis (months)b | 1.02 | 1.01-1.02 | <0.001 | 1.02 | 1.01-1.03 | <0.001 |
| Pre-emptive transplantationb | 0.74 | 0.54-1.02 | 0.063 | 0.67 | 0.42-1.08 | 0.106 |
| HD vs. PD | 1.27 | 0.95-1.70 | 0.101 | 1.27 | 0.83-1.93 | 0.278 |
| Donor agec | 1.02 | 1.01-1.02 | <0.001 | 1.02 | 1.01-1.02 | <0.001 |
| Donor > 60 yearsc | 1.54 | 1.24-1.91 | <0.001 | 1.57 | 1.23-2.00 | <0.001 |
| Male donor | 0.97 | 0.79-1.20 | 0.800 | |||
| CMV positive donor | 1.23 | 0.97-1.58 | 0.094 | 1.06 | 0.81-1.39 | 0.664 |
| CMV positive recipient | 0.81 | 0.63-1.06 | 0.119 | 0.86 | 0.66-1.13 | 0.285 |
| Cold ischemia time (CIT) | 1.00 | 0.98-1.02 | 0.957 | |||
| Any HLA-A mismatch | 0.78 | 0.60-1.00 | 0.05 | 0.73 | 0.56-0.96 | 0.025 |
| Any HLA-B mismatch | 1.28 | 0.91-1.80 | 0.160 | 1.42 | 0.98-2.07 | 0.066 |
| Any HLA-DR mismatch | 1.23 | 0.99-1.51 | 0.061 | 1.00 | 0.79-1.26 | 0.998 |
| Induction therapy | 0.82 | 0.66-1.03 | 0.089 | 0.67 | 0.52-0.87 | 0.003 |
| CNI | 0.88 | 0.55-1.42 | 0.605 | |||
| CSA vs. Tacrolimus | 1.14 | 0.80-1.64 | 0.477 | |||
| MMF | 0.77 | 0.55-1.08 | 0.123 | 0.61 | 0.42-0.90 | 0.011 |
| mTOR | 0.51 | 0.21-1.24 | 0.137 | 0.63 | 0.26-1.54 | 0.307 |
| PRA positive | 0.93 | 0.58-1.49 | 0.752 | |||
| Any acute rejection | 1.11 | 0.87-1.42 | 0.393 | |||
| Glomerulonepritis | 0.68 | 0.53-0.89 | 0.005 | 0.63 | 0.45-0.89 | 0.008 |
| Pyelonephritis | 0.90 | 0.56-1.47 | 0.687 | 0.65 | 0.37-1.13 | 0.124 |
| Polycystic kidney disease | 0.80 | 0.58-1.10 | 0.172 | 0.68 | 0.46-1.02 | 0.064 |
| Vascular nephropathy | 1.24 | 1.00-1.44 | 0.051 | 0.87 | 0.64-1.18 | 0.373 |
| Diabetes nephropathya | 1.31 | 0.91-1.90 | 0.151 | 1.01 | 0.64-1.59 | 0.970 |
aDiabetes and diabetes nephropathy were tested i separate multivariable models. Diabetes was selected in the final model
bPre-emptive transplantation and time on dialysis/dialysis mode were tested in separate multivariable models. In the final model, pre-emptive transplantation was excluded
cDonor > 60 years and Donor age were tested in separate multivariable models. Only the continuous variable Donor age was included in the final model