Table 3.

Capacity of splenic subset to induce a cytotoxic T cell response

Peptide	No. APC from Actm-OVA mice used for priminga Targets:	Concentration of peptide (uM) required to activate CTL for 50% lysis of targets
		L-DC	Resi Mono	CD8+cDC
SIIN	90 K	0.1	0.1	1.0
	9 K	10.0	> > 10	10.0
	0.9 K	0	0	0
N6	90 K	0.001	0.001	0.001
	9 K	0.01	1.0	0.01
	0.9 K	0	0	0
G4	90 K	0	0	0
	9 K	0	0	0
	0.9 K	0	0	0
E1	90 K	0	0	0
	9 K	0	0	0
	0.9 K	0	0	0

^a The table summarises data obtained from the fluorescent target experiment described in Fig. 3. Mice were given sorted OT-I CD8⁺ T cells ahead of APC sorted from Act-mOVA mice. These included L-DC, Resident monocytes (Resi mono) and CD8⁺ cDC. Target cells were added after 6 days, and their lysis measured in terms of % cell recovery at 24 h