Table 3. Pathways significantly overrepresented in the genes differentially expressed in cluster headache.

Pathway	Threshold DEGs P < 0.05		Threshold DEGs P < 0.01
	P-value	Count	P-value	Count
GABA Receptor Signaling	0.00053	13	0.043	4
Calcium-induced T Lymphocyte Apoptosis	0.0015	18	0.028	6
Nur77 Signaling in T Lymphocytes	0.0066	15	0.0040	7
CD28 Signaling in T Helper Cells	0.0098	28	0.021	10
Cdc42 Signaling	0.015	29	0.014	11
Role of BRCA1 in DNA Damage Response	0.017	21	0.023	8
IGF-1 Signaling	0.022	24	0.025	9
Actin Nucleation by ARP-WASP Complex	0.023	15	0.0083	7
Prolactin Signaling	0.026	19	0.041	7
IL-4 Signaling	0.026	19	0.041	7
PTEN Signaling	0.043	25	0.045	9
Telomerase Signaling	0.044	23	0.026	9

P-value thresholds for differential gene expression are P < 0.05 and P < 0.01. Pathways are included if overrepresented in lists of differentially expressed genes based on both P-value thresholds. DEGs: differentially expressed genes.