Table 1. Positive selection on FGF genes.
| Gene | Length | M2 |
M1 |
diff | p value | adjusted p value | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| p0 | p1 | p2 | ω0 | ω2 | L | p0 | p1 | ω0 | L | |||||
| FGF1 | 459 | 0.993 | 0 | 0.006 | 0.019 | 20.467 | −728.86 | 0.956 | 0.043 | 0 | −732.42 | 7.10 | 0.0286 | 0.3011 |
| FGF2 | 453 | 0.990 | 0 | 0.009 | 0 | 8.096 | −688.43 | 0.960 | 0.039 | 0 | −689.63 | 2.39 | 0.3017 | 1 |
| FGF3 | 480 | 0.841 | 0.151 | 0.006 | 0.024 | 36.996 | −919.43 | 0.843 | 0.156 | 0.020 | −925.36 | 11.86 | 0.0026 | 0.0556 |
| FGF4 | 588 | 1 | 0 | 0 | 0.038 | 1 | −927.87 | 1 | 1E-005 | 0.038 | −927.87 | 0.00 | 0.9996 | 1 |
| FGF5 | 747 | 0.812 | 0.078 | 0.108 | 0.165 | 1 | −1296.74 | 0.812 | 0.187 | 0.165 | −1296.74 | 0 | 1 | 1 |
| FGF6 | 618 | 0.871 | 0.108 | 0.019 | 0 | 1 | −1074.37 | 0.871 | 0.128 | 0 | −1074.37 | 0 | 1 | 1 |
| FGF7 | 579 | 0.991 | 0 | 0.008 | 0 | 16.169 | −813.34 | 0.925 | 0.074 | 0 | −813.45 | 0.21 | 0.8980 | 1 |
| FGF8 | 408 | 1 | 0 | 0 | 0 | 6.838 | −624.81 | 1 | 1E-005 | 0 | −624.81 | 0.00 | 0.9993 | 1 |
| FGF9 | 624 | 1 | 0 | 0 | 0.152 | 1 | −941.66 | 1 | 1E-005 | 0.152 | −941.66 | 0.00 | 0.9999 | 1 |
| FGF10 | 588 | 1 | 0 | 0 | 0.085 | 1 | −936.85 | 1 | 1E-005 | 0.085 | −936.85 | 0.00 | 0.9999 | 1 |
| FGF11 | 567 | 0.544 | 0.317 | 0.137 | 0.254 | 1 | −914.52 | 0.544 | 0.455 | 0.254 | −914.52 | 0 | 1 | 1 |
| FGF12 | 720 | 1 | 0 | 0 | 0 | 1 | −1063.87 | 1 | 1E-005 | 0 | −1063.87 | 0.00 | 0.9996 | 1 |
| FGF13 | 675 | 1 | 0 | 0 | 0 | 1 | −990.05 | 1 | 1E-005 | 0 | −990.05 | 0.00 | 0.9996 | 1 |
| FGF14 | 738 | 1 | 0 | 0 | 0.029 | 1 | −1130.69 | 1 | 1E-005 | 0.029 | −1130.69 | 0.00 | 0.9999 | 1 |
| FGF16 | 621 | 0.994 | 0 | 0.005 | 0 | 12.639 | −968.58 | 0.984 | 0.015 | 0 | −970.56 | 3.95 | 0.1384 | 0.9688 |
| FGF17 | 645 | 1 | 0 | 0 | 0.019 | 1 | −993.48 | 1 | 1E-005 | 0.019 | −993.48 | 0.00 | 0.9997 | 1 |
| FGF18 | 615 | 1 | 0 | 0 | 0.014 | 13.185 | −865.28 | 1 | 1E-005 | 0.014 | −865.28 | 0.00 | 0.9999 | 1 |
| FGF19 | 525 | 1 | 0 | 0 | 0.038 | 1 | −919.46 | 1 | 1E-005 | 0.038 | −919.46 | 0.00 | 0.9998 | 1 |
| FGF20 | 630 | 1 | 0 | 0 | 0.023 | 1 | −949.80 | 1 | 1E-005 | 0.023 | −949.80 | 0.00 | 0.9999 | 1 |
| FGF21 | 600 | 1 | 0 | 0 | 0.207 | 1 | −1161.23 | 1 | 1E-005 | 0.207 | −1161.23 | 0.00 | 0.9999 | 1 |
| FGF23 | 576 | 0.939 | 0.025 | 0.034 | 0.041 | 1 | −961.53 | 0.939 | 0.060 | 0.041 | −961.53 | 0 | 1 | 1 |
The results of the site model for each FGF genes. M2 is a selection model that allows local dN/dS ratio to be higher than 1. p0, p1, and p2 are the proportions of codons with dN/dS lower than 1, equals to 1, and higher than 1, respectively, and ω0 and ω2 are the average dN/dS ratio of codons with dN/dS < 1 and dN/dS > 1, respectively. M1 is a neutral model that does not allow local dN/dS ratio to be higher than 1. In this model, p0 and p1 are the proportions of codons with dN/dS lower than 1 and dN/dS equal to 1, respectively and ω0 is the average dN/dS ratio of codons with dN/dS lower than 1. The p values are calculated using likelihood ratio test (degree of freedom = 2) and further adjusted by the false discovery rate.