Table 2. Functional effect of ancestral cetacean mutations.
| Genes | Accession number | Position | From | To | PolyPhen-2 | SIFT | PROVEAN |
|---|---|---|---|---|---|---|---|
| FGF3 | NP_005238.1 | 102 | R | K | benign | Tolerated | Neutral |
| FGF5 | NP_004455.2 | 54 | M | K | benign | Tolerated | Neutral |
| FGF9 | NP_002001.1 | 17 | V | A | benign | Tolerated | Neutral |
| FGF9 | NP_002001.1 | 27 | V | A | benign | Tolerated | Neutral |
| FGF9 | NP_002001.1 | 203 | D | G | Probably damaging | Damaging | Deleterious |
| FGF10 | NP_004456.1 | 43 | D | G | benign | Damaging | Neutral |
| FGF11 | NP_004103.1 | 63 | G | C | Probably damaging | Tolerated | Neutral |
| FGF14 | NP_787125.1 | 197 | P | A | benign | Tolerated | Neutral |
| FGF19 | NP_005108.1 | 113 | L | S | Possibly damaging | Tolerated | Neutral |
| FGF19 | NP_005108.1 | 177 | E | D | benign | Tolerated | Neutral |
| FGF20 | NP_062825.1 | 46 | R | L | benign | Damaging | Neutral |
| FGF21 | NP_061986.1 | 107 | D | E | benign | Tolerated | Neutral |
| FGF21 | NP_061986.1 | 119 | E | Q | benign | Damaging | Neutral |
List of amino acid changes that were generated in the ancestral cetacean. The name of genes, accession number, position in the alignment, and the functional prediction using PolyPhen-2, SIFT, and PROVEAN are shown.